In multiple myeloma, monoclonal immunoglobulin light chains combine with Tamm-Horsfall protein precipitate in the renal tubules which leads to the development of which one of the following conditions?
Cast Nephropathy
Free monoclonal light chains bind to Tamm-Horsfall (uromodulin) protein in the distal tubule forming obstructive casts, a process that defines myeloma cast nephropathy — the classic cause of 'myeloma kidney' and acute kidney injury in multiple myeloma.
Important Questions from Renal Failure
Which of the following statements are correct regarding anti-glomerular basement membrane disease?
1. It is a rare autoimmune disease which presents as rapidly progressive glomerulonephritis.
2. Antibodies are formed against $α3$ chain of type 4 collagen GBM.
3. The $α3$ chain is expressed in basement membrane of glomerulus and the retina.
4. The disease may be associated with retinal hemorrhage when it is known as Goodpasture syndrome.
Select the answer using the code given below :
Which of the following are poor prognostic indictators in glomerular disease?
1. Female sex
2. Hypertension
3. Persistent and severe proteinuria
4. Elevated creatinine levels at presentation
Select the correct answer using the code given below:
Which of the following are indications for a renal biopsy?
1. Chronic kidney disease of uncertain etiology
2. Nephritic syndrome
3. Uncontrolled severe hypertension
4. Renal transplant dysfunction
Select the correct answer using the code given below:
- Which of the following is the correct range of Glomerular Filtration Rate (GFR) for Stage 2 chronic kidney disease?
Which of the following drugs are effective in preventing uric acid nephropathy in patients receiving chemotherapy?
1. Probenecid
2. Forced saline diuresis
3. Rasburicase
4. Acetazolamide
Select the correct answer using the code given below.
