With regard to hypertrophic cardiomyopathy, match List I with List II and select the correct answer using the code given below the lists: List I (Mutation) List II (Phenotype) A. Beta-myosin heavy chain mutations
B. Troponin mutations
C. Myosin-binding protein-C mutations1. Marked ventricular hypertrophy
2. Hypertension and arrhythmia
3. Myocardial fibre disarray with minimal hypertrophy
A-1, B-3, C-2
Beta-myosin heavy chain (MYH7) mutations cause marked ventricular hypertrophy (most common, high-penetrance HCM genotype). Troponin T (TNNT2) mutations cause myofibre disarray with minimal or absent hypertrophy but a disproportionately high risk of sudden arrhythmic death. Myosin-binding protein-C (MYBPC3) mutations typically present later in life with a milder, more variable phenotype. This gives A-1, B-3, C-2.
Important Questions from Ischemic Heart Disease
- A 60-year-old diabetic female presents with acute myocardial infarction. ECG changes include ST elevation greater than 1 mm in lead aVR. The likely localization of thrombosis is in
- An elderly-man with history of Diabetes mellitus and Coronary Artery Disease comes for follow-up, with complaints of muscle pains. Which one of the following drugs could be the most likely cause?
- All of the following are indications for treadmill testing/exercise-testing EXCEPT:
A 60-year-old man comes to emergency with history of chest pain, which is acute onset. The ECG shows ST depression and T waves inversion. Cardiac biomarkers in blood are not elevated. What will be the appropriate management?
- Which one of the following is not a differential diagnosis of ST segment elevation in ECG?
