Consider the following statements regarding Eisenmenger Syndrome: 1. In patients with severe and prolonged pulmonary hypertension, the right-to-left shunt gets reversed to a left-to-right shunt. 2. There is marked cyanosis, which may be more apparent in the feet and toes than in the upper part of the body. 3. Antihypertensives which cause peripheral vasodilatation can exacerbate the shunting and worsen the symptoms. Which of the statements given above is/are correct?
2 and 3
In Eisenmenger syndrome, the original left-to-right shunt reverses to a right-to-left shunt due to prolonged pulmonary hypertension, so statement 1 is worded incorrectly (reversed direction). Differential cyanosis with more pronounced cyanosis/clubbing in the lower extremities (feet/toes) is a classic feature when the shunt is at the ductal level (statement 2 correct). Peripheral vasodilators reduce systemic vascular resistance, which increases right-to-left shunting and worsens cyanosis (statement 3 correct). Hence 2 and 3 are correct.
Consider the following statements regarding Takotsubo cardiomyopathy:
1. There is acute right ventricular dysfunction characterized by dilatation of the right ventricular apex.
2. It can be precipitated by acute emotional stress and is frequently associated with an underlying neuro-psychiatric disorder.
3. Symptoms and ECG findings often mimic acute ST-elevation myocardial infarction.
4. Ventriculography shows normal left ventricle and apical ballooning of the right ventricle.
Which of the statements given above are correct?
With regard to hypertrophic cardiomyopathy, match List I with List II and select the correct answer using the code given below the lists:
| List I (Mutation) | List II (Phenotype) |
| A. Beta-myosin heavy chain mutations B. Troponin mutations C. Myosin-binding protein-C mutations | 1. Marked ventricular hypertrophy 2. Hypertension and arrhythmia 3. Myocardial fibre disarray with minimal hypertrophy |
'Tumour Plop' is a characteristic auscultatory finding seen in which one of the following conditions?
Consider the following statements regarding the murmur of Patent Ductus Arteriosus:
1. It is a continuous 'machinery' murmur.
2. There is a late diastolic accentuation.
3. It is maximal in the second left intercostal space below the clavicle.
4. With the development of Eisenmenger Syndrome, the murmur becomes louder and rumbling in character.
Which of the statements given above is/are correct?