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Question

Consider the following statements regarding Eisenmenger Syndrome:

1. In patients with severe and prolonged pulmonary hypertension, the right-to-left shunt gets reversed to a left-to-right shunt.

2. There is marked cyanosis, which may be more apparent in the feet and toes than in the upper part of the body.

3. Antihypertensives which cause peripheral vasodilatation can exacerbate the shunting and worsen the symptoms.

Which of the statements given above is/are correct?

This question was previously asked in
UPSC CMS 2026 Surgery, Gynaecology & Obstetrics, and PSM Question Paper (02-Aug-2026)
The correct answer is

2 and 3

In Eisenmenger syndrome, the original left-to-right shunt reverses to a right-to-left shunt due to prolonged pulmonary hypertension, so statement 1 is worded incorrectly (reversed direction). Differential cyanosis with more pronounced cyanosis/clubbing in the lower extremities (feet/toes) is a classic feature when the shunt is at the ductal level (statement 2 correct). Peripheral vasodilators reduce systemic vascular resistance, which increases right-to-left shunting and worsens cyanosis (statement 3 correct). Hence 2 and 3 are correct.

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