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Question

'Melanosis coli' (brownish discoloration of colonic mucosa) can occur due to the long-term consumption of which one of the following?

This question was previously asked in
UPSC CMS 2026 Surgery, Gynaecology & Obstetrics, and PSM Question Paper (02-Aug-2026)
The correct answer is

Stimulant laxatives

Melanosis coli is a benign, reversible brownish-black pigmentation of the colonic mucosa caused by apoptotic epithelial cell debris laden with lipofuscin-like pigment, classically resulting from chronic use of anthraquinone-containing stimulant laxatives (e.g., senna, cascara).

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Important Questions from Peptic Ulcer Disease

  1. With regard to Helicobacter pylori eradication in peptic ulcer disease, consider the following statements: 

    1. Proton-pump inhibitor is taken with two antibiotics. 

    2. Treatment is prescribed for at least 7 days. 

    3. Treatment of Helicobacter pylori infection leads to vitamin B12 deficiency. 

    4. Patients requiring long-term NSAIDS should undergo Helicobacter pylori eradication therapy to reduce ulcer risk. 

    Which of the statements given above are correct?

  2. Which one of the following statements is correct with regard to peptic ulcer prophylaxis?
  3. The investigation of choice for early follow-up in patients treated for anti-$H.$ pylori drugs is
  4. The most common non-pancreatic site for tumour distribution in Zollinger-Ellison syndrome is
  5. Helicobacter pylori infection is associated with the development of which one of the following lymphoid malignancies?
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