Consider the following statements regarding 'Barrett's Oesophagus': 1. It is a pre-malignant condition. 2. The normal columnar mucosa of lower oesophagus is replaced by squamous cells. 3. It is an adaptive response to chronic gastro-oesophageal reflux. Which of the statements given above is/are correct?
1 and 3 only
Barrett's oesophagus is a pre-malignant condition (statement 1 correct) that develops as a metaplastic adaptive response to chronic gastro-oesophageal reflux disease (statement 3 correct). However, the change is the reverse of statement 2 — the normal stratified squamous epithelium of the lower oesophagus is replaced by columnar (intestinal-type) epithelium, not squamous replacing columnar. Hence statements 1 and 3 only are correct.
A 30-year-old female with irritable bowel syndrome presents with predominant symptom of diarrhea. Which of the following will be helpful in her treatment?
1. Loperamide
2. Lactulose
3. Lubiprostone
4. Sorbitol
Select the correct answer using the code given below:
'Melanosis coli' (brownish discoloration of colonic mucosa) can occur due to the long-term consumption of which one of the following?
The '13C-urea breath test' and the 'faecal antigen test' are non-invasive techniques to diagnose infection with which one of the following?
Patients suffering from which of the following condition(s) can get symptomatic relief by consuming a gluten-free diet?
1. Coeliac disease
2. Peptic ulcer disease
3. Dermatitis herpetiformis
Select the correct answer using the code given below:
Consider the following statements regarding Ménétrier's disease:
1. There is excessive production of Transforming Growth Factor-alpha (TGF-alpha).
2. Majority of the patients present with features of protein-losing enteropathy.
3. Mucus secreting cells are replaced by parietal and chief cells.
4. The mucosal folds of the body and fundus of the stomach are greatly enlarged.
Which of the statements given above are correct?
The presence of which of the following is suggestive of metastatic spread of an underlying gastrointestinal malignancy?
1. Krukenberg Tumour
2. Virchow's Node
3. Meigs' Syndrome
4. Sister Mary Joseph's Nodule
Select the correct answer using the code given below:
Risk scoring system used to stratify the patients of acute upper gastrointestinal bleeding to predict the need for intervention to treat bleeding is: