Consider the following statements regarding Ménétrier's disease: 1. There is excessive production of Transforming Growth Factor-alpha (TGF-alpha). 2. Majority of the patients present with features of protein-losing enteropathy. 3. Mucus secreting cells are replaced by parietal and chief cells. 4. The mucosal folds of the body and fundus of the stomach are greatly enlarged. Which of the statements given above are correct?
1, 2 and 4
Ménétrier's disease is characterized by TGF-alpha overexpression driving foveolar hyperplasia (statement 1 correct), massive gastric protein loss causing hypoalbuminemia and protein-losing enteropathy (statement 2 correct), and giant, greatly enlarged rugal folds in the body and fundus (statement 4 correct). However, the pathology is the opposite of statement 3 — parietal and chief cells are replaced/atrophied and substituted by mucus-secreting foveolar cells, not the reverse. Hence statements 1, 2 and 4 are correct.
Important Questions from Peptic Ulcer Disease
With regard to Helicobacter pylori eradication in peptic ulcer disease, consider the following statements:
1. Proton-pump inhibitor is taken with two antibiotics.
2. Treatment is prescribed for at least 7 days.
3. Treatment of Helicobacter pylori infection leads to vitamin B12 deficiency.
4. Patients requiring long-term NSAIDS should undergo Helicobacter pylori eradication therapy to reduce ulcer risk.
Which of the statements given above are correct?
- Which one of the following statements is correct with regard to peptic ulcer prophylaxis?
- The investigation of choice for early follow-up in patients treated for anti-$H.$ pylori drugs is
- The most common non-pancreatic site for tumour distribution in Zollinger-Ellison syndrome is
- Helicobacter pylori infection is associated with the development of which one of the following lymphoid malignancies?
