Infiltration of the small-intestine mucosa with 'foamy' macrophages, which stain positive with Periodic Acid-Schiff (PAS) reagent, is a characteristic feature of which one of the following conditions?
Whipple's disease
Whipple's disease, caused by the bacterium Tropheryma whipplei, is classically characterized by infiltration of the small-intestinal lamina propria with PAS-positive foamy macrophages containing the bacillus. This is a key diagnostic histological finding distinguishing it from coeliac disease, tropical sprue, and radiation enteropathy.
Similar Questions
Infusion of which one of the following antibacterial agents may cause the 'Red Man Syndrome' characterized by rapid onset of erythematous rash and pruritus on the head, face, neck and upper trunk?
A 35-year-old female presents with generalized muscle rigidity, difficulty in swallowing and laryngeal spasms for the past one week. She has developed trismus over the past 2 days and has a pulse rate of 130 beats/minute and a respiratory rate of 35 breaths/minute on presentation. She gives a history of getting her ears pierced from a roadside jewellery seller 2 weeks ago. What is the most probable diagnosis?
A 25-year-old male presents with complaints of urethral discharge and dysuria for the past 1 week. The discharge was scant and mucoid for a few days but he reports profuse and yellowish discharge since 2 days. Gram staining of the urethral discharge reveals gram-negative intracellular monococci and diplococci. On further questioning, he gives a history of unprotected sexual intercourse 15 days ago. Which one of the following conditions will be your most probable diagnosis?
Consider the following statements regarding gas gangrene: 1. It is caused by clostridial species, e.g., Clostridium perfringens. 2. It is characterized by a foul-smelling, painful wound containing serosanguineous discharge and gas bubbles. 3. It requires an aerobic environment and affects sites which are richly supplied with blood. 4. Radical amputation carries a high risk of advancing the infection to healthy tissue and is strictly contraindicated. Which of the statements given above are correct? (a) 1 and 2 (b) 2 and 3 (c) 3 and 4 (d) 1 and 4
Which of the following correctly denote(s) the clinical manifestations of diphtheria? 1. Dermatosis characterized by punched-out ulcerative lesions with necrotic sloughing 2. Dysphonia, dysphagia and headache 3. Myocarditis, cardiac arrhythmias and congestive heart failure 4. Massive tonsillar, submandibular and paratracheal oedema presenting as 'bull-neck' appearance. Select the correct answer using the code given below: (a) 1 only (b) 1 and 3 only (c) 2 and 3 only (d) 1, 2, 3 and 4
The neuropsychiatric manifestations of the infections caused by which one of the following infectious agents presents as 'Muttering Delirium' or 'Coma Vigil' in which patients pick randomly at bed clothes or imaginary objects?
Important Questions from Bacterial Infections
- A 21-year young man presents in emergency with high grade fever with inflammation of knee and ankle joints which is fleeting in nature. There is history of occasional palpitations. There is no history of antecedent sore throat. On examination, splenomegaly is present. The ECG shows prolongation of PR interval. What is the most likely diagnosis in India?
- Long term use of proton pump inhibitor in elderly puts the patient at risk of which of the following?
1. Community acquired pneumonia
2. Clostridium difficile associated disease
3. Urinary tract infection
Select the correct answer using the code given below: - Which of the following features are characteristics of Whipple disease?
1. Migratory small joint arthropathy
2. Diarrhoea with steatorrhea
3. Weight loss with Arthralgia
4. Ophthalmic and CNS symptoms
Select the correct answer using the code given below: - Which of the following infections does NOT cause cold antibodies immune haemolysis?
- A 22-year old male is admitted with fever and altered consciousness for two days. Examination reveals nuchal rigidity and diffuse petechial rash on the trunk and lower extremities. The most likely etiologic agent is:
