1. Migratory small joint arthropathy
2. Diarrhoea with steatorrhea
3. Weight loss with Arthralgia
4. Ophthalmic and CNS symptoms
Select the correct answer using the code given below:
Analyzing Whipple Disease Characteristics
Whipple disease is a rare infectious disease caused by the bacterium Tropheryma whipplei. It primarily affects the small intestine but can manifest systemically. Let's evaluate the features listed:
- 1. Migratory small joint arthropathy: While joint pain (arthralgia) and arthritis are common in Whipple disease, this specific description might be considered less defining or overlapping compared to other features in the context of the question's options.
- 2. Diarrhoea with steatorrhea: These are classic gastrointestinal symptoms. Malabsorption resulting in fatty stools (steatorrhea) and chronic diarrhoea are hallmark signs due to bacterial infiltration of the intestinal lining.
- 3. Weight loss with Arthralgia: Significant weight loss is a very common constitutional symptom resulting from malabsorption. Joint pain (arthralgia) is also frequently reported. This combination represents key systemic and musculoskeletal manifestations.
- 4. Ophthalmic and CNS symptoms: Although less common than gastrointestinal or joint symptoms, Whipple disease can affect the eyes (e.g., uveitis) and the central nervous system (CNS), leading to neurological deficits. These represent important systemic involvements.
Conclusion on Whipple Disease Features
Based on the typical presentation, features 2 (Diarrhoea with steatorrhea), 3 (Weight loss with Arthralgia), and 4 (Ophthalmic and CNS symptoms) are considered significant characteristics of Whipple disease. Feature 1, while related to joint symptoms, is often subsumed or less emphasized compared to the combination presented in features 2, 3, and 4.
Therefore, the correct option includes features 2, 3, and 4.
Important Questions from Bacterial Infections
- A 21-year young man presents in emergency with high grade fever with inflammation of knee and ankle joints which is fleeting in nature. There is history of occasional palpitations. There is no history of antecedent sore throat. On examination, splenomegaly is present. The ECG shows prolongation of PR interval. What is the most likely diagnosis in India?
- Long term use of proton pump inhibitor in elderly puts the patient at risk of which of the following?
1. Community acquired pneumonia
2. Clostridium difficile associated disease
3. Urinary tract infection
Select the correct answer using the code given below: - Which of the following infections does NOT cause cold antibodies immune haemolysis?
- A 22-year old male is admitted with fever and altered consciousness for two days. Examination reveals nuchal rigidity and diffuse petechial rash on the trunk and lower extremities. The most likely etiologic agent is:
A 30 year old male presents with fever, headache, anorexia, nausea, vomiting and diarrhoea. On examination tongue is coated with abdominal tenderness, soft splenomegaly, relative bradycardia and rose spots rash. The most likely diagnosis is:
