Enumerate the cells of lymphoreticular system. Schematically represent the process of B-cell maturation.
Cells of the Lymphoreticular System: Include lymphocytes (B, T, NK cells), phagocytes (macrophages, monocytes, dendritic cells, neutrophils), reticular stromal cells, plasma cells (differentiated B cells), and mast cells.
B-cell Maturation: Begins in the bone marrow from hematopoietic stem cells → Pro-B cell (heavy chain V-D-J recombination) → Pre-B cell (light chain V-J recombination) → Immature B cell (IgM expression; negative selection removes self-reactive cells) → Mature naive B cell (IgM and IgD) migrates to secondary lymphoid organs. Upon antigen encounter with T-cell help, cells proliferate and differentiate into plasma cells (antibody secretion) or memory B cells, ensuring humoral immunity and rapid response upon re-exposure.
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