Describe steps of wound healing by first intention. Enumerate factors that influence tissue repair.
Wound Healing by First Intention (Primary Union):
Occurs in clean, uninfected wounds with well-approximated edges, such as surgical incisions or minor cuts.
Initial Hemostasis & Inflammation (Day 0–2): Blood clot forms, filling the wound gap. Neutrophils migrate to clear debris, bacteria, and necrotic tissue, initiating the inflammatory response.
Proliferation & Epithelialization (Day 2–5): Basal epidermal cells at the wound margins proliferate and migrate beneath the clot, forming a continuous epithelial layer. Fibroblasts infiltrate and deposit collagen, while angiogenesis produces new capillaries, creating granulation tissue.
Maturation & Remodeling (Week 2 onwards): Collagen deposition increases tensile strength. Granulation tissue is gradually replaced by a pale, avascular scar. Collagen fibers reorganize, and fibroblasts differentiate into myofibroblasts, aiding contraction. Scar tissue becomes less cellular and vascular over weeks to months.
Factors Influencing Healing: Systemic: Nutrition, diabetes, circulation, hormones, age, comorbidities. Local: Infection, mechanical stress, foreign bodies, wound type, ischemia, and radiation therapy.
Answered By:
Harsh Raj
Harsh Raj is a successful government exam expert, having cleared multiple stages of SSC CGL, IBPS PO, CDS, RRB NTPC, and Delhi Police SI exams himself and mentored more than 5000 students through direct mentorship. His expertise is in creating well researched content, especially MCQs, which have been directly asked by relevant commissions in multiple exams.
Similar Questions
Classify jaundice according to its aetiology. Make a tabular representation of the blood, urinary and stool findings observed in different types ofjaundice.
Describe the formation, course and branches of ulnar nerve. Which muscles do each of the branches supply? Why is ulnar nerve called the "musician's nerve"?
Name the nerves and their branches that supply the sole of the foot stating the specific area of their distribution. Explain in brief what is Morton's metatarsalgia.
With the help of a suitable diagram, explain the innervation and functions of muscle spindle.
Describe the process of generation and conduction of nerve impulses in humans. Add a note on saltatory conduction.
Using a well labelled diagram, trace the taste pathway from circumvallate papillae of tongue to the cerebral cortex.
Enumerate any five tests for the assessment of renal tubular functions. Explain the underlying principle and their interpretation.
Explain the role of biotin in intermediary metabolism with suitable examples. Add a note on the mechanism of action of any biotin-antagonist with its application in medicine.
Define Systemic Vascular Resistance and list its determinants. Briefly explain the role of its determinants.
Define cardiac output and describe the regulation of cardiac output in normal adults. Add a note on Cardiac Index and Cardiac Reserve.
Important Questions from Miscellaneous
Write a note in 150 words
Mendelian and non-Mendelian traits.Write a note in 150 words
Theoretical significance of Purum kinship-system.Write a note in 150 words
Smell as a signal among non-human primates.Write a note in 150 words
Osteodontokeratik culture and its makers.Discuss the Miocene hominoid remains and their significance in evolution.
