Name antihelmintic drugs used in treatment of neurocysticercosis and also mention their side effects.
Neurocysticercosis, caused by Taenia solium larvae in the CNS, is treated with Albendazole and Praziquantel.
Albendazole can cause headache, nausea, vomiting, abdominal pain, and reversible liver enzyme elevation. Rapid parasite death may trigger inflammatory reactions, worsening seizures or intracranial pressure, often managed with corticosteroids.
Praziquantel has similar side effects, including headache, dizziness, nausea, and malaise. Inflammatory responses from cyst destruction also necessitate corticosteroid use to control neurological symptoms.
Both drugs are effective in cyst eradication, but careful management of the host inflammatory response is essential to prevent exacerbation of neurological manifestations and ensure safe, effective treatment.
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