Liquorice misuse, by inhibiting 11 beta-hydroxysteroid dehydrogenase type 2 enzyme, can cause a condition which resembles the clinical features of:
Mineralocorticoid excess
11-beta-hydroxysteroid dehydrogenase type 2 normally inactivates cortisol to cortisone in mineralocorticoid-responsive tissues. Liquorice (glycyrrhizic acid) inhibits this enzyme, allowing cortisol to act on mineralocorticoid receptors, causing apparent mineralocorticoid excess (hypertension, hypokalemia, metabolic alkalosis).
Similar Questions
With regard to the treatment of phaeochromocytoma, beta-blocker should never be given before alpha-blocker because it may cause:
Which of the following is/are growth hormone receptor antagonist(s) indicated in the treatment of Acromegaly?
1. Octreotide
2. Lanreotide
3. Pasireotide
4. Pegvisomant
Select the correct answer using the code given below:
Which of the following statements regarding Autoimmune Polyendocrine Syndromes (APS) is/are correct?
1. APS Type 1 is more common than APS Type 2.
2. APS Type 1 is inherited as an autosomal recessive condition.
3. APS Type 2 is inherited as an autosomal dominant condition.
Select the correct answer using the code given below:
Important Questions from Adrenal Disorders
- Match the List I with List II and select the correct answer using the code given below the lists:
List I
(disease)List II
(signs)A. Conn syndrome 1. Anosmia B. Turner syndrome 2. Tetany C. Kallman syndrome 3. Lymphoedema D. Cushing syndrome 4. Avascular necrosis of hip
Code: - Which of the following test has maximum sensitivity for diagnosing Pheochromocytoma?
- A 26 year old lady has a Prolactinoma (microadenoma). The best modality of treatment for her condition is:
- Escape behaviour with paroxysmal occurrence is seen in:
- Hirsutism is seen in which of the following ?
1. Polycystic ovarian syndrome
2. Congenital adrenal hyperplasia
3. Hypothyroidism
4. Ovarian tumour
Select the correct answer using the code given below:
