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Question

With regard to the treatment of phaeochromocytoma, beta-blocker should never be given before alpha-blocker because it may cause:

This question was previously asked in
UPSC CMS 2026 Surgery, Gynaecology & Obstetrics, and PSM Question Paper (02-Aug-2026)
The correct answer is

Paradoxical rise in blood pressure due to unopposed alpha-mediated vasoconstriction

In pheochromocytoma, catecholamine excess acts on both alpha and beta receptors. Blocking beta receptors first removes vasodilatory/compensatory beta-2 effects, leaving alpha-mediated vasoconstriction unopposed, causing a dangerous paradoxical rise in blood pressure (hypertensive crisis).

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