Anti-PLA2R antibodies, which are directed against the 'M-type phospholipase A2 receptor', are a key biomarker for which one of the following conditions?
Primary membranous nephropathy
Anti-PLA2R antibodies are found in roughly 70-80% of patients with primary (idiopathic) membranous nephropathy and are used both as a diagnostic biomarker and to monitor disease activity/treatment response, distinguishing it from secondary membranous nephropathy.
A 40-year-old female with nephritic range proteinuria is found to have low serum complement levels. Which of the following can be the likely etiology?
1. Systemic lupus erythematosus
2. Post-infectious glomerulonephritis
3. Infective endocarditis
4. Mesangio-capillary glomerulonephritis
Select the correct answer using the code given below: