Which one of the following hereditary neuropathies is characterized by elevated serum 'phytanic acid' levels and manifests with the tetrad of peripheral neuropathy, retinitis pigmentosa, cerebellar ataxia and elevated protein concentration in cerebrospinal fluid?
Refsum's disease
Refsum's disease is caused by a defect in phytanoyl-CoA hydroxylase leading to accumulation of phytanic acid, and classically presents with the tetrad of peripheral neuropathy, retinitis pigmentosa, cerebellar ataxia, and elevated CSF protein without pleocytosis.
Important Questions from Neuropathies
Consider the following clinical features :
1. Hypomimia
2. Dysphonia
3. Festination gait
4. Cogwheel rigidity
Which of the features given above are generally present in Parkinsonism?
- Circuits between the basal ganglia and the motor cortex constitute the extra pyramidal system which controls muscle tone, body posture and the initiation of movement. Lesions of the extra pyramidal system present clinically with :
Consider the following statements regarding Transient Global Amnesia (TGA):
1. TGA mainly affects middle aged persons who present with abrupt, discrete loss of anterograde memory lasting for few hours.
2. During the episode, the patients are unable to record new memories resulting in repetitive questioning.
3. Consciousness is impaired during the episode and the patient is unable to perform even simple motor functions.
4. After 4-6 hours, memory function and behaviour return to normal but the patient has complete and persistent amnesia for the duration of the episode.
Which of the statements given above are correct?
- Which of the following correctly describes the primary position of the right eye in right 3rd cranial nerve palsy?
- Which one of the following distinguishes axonal degeneration from segmental demyelination on electrophysiological studies?
