Consider the following pairs with respect to muscle channelopathies: Which of the pairs given above are correctly matched?Channel Muscle disease 1. Sodium
2. Calcium
3. Ryanodine receptor
4. ChlorideParamyotonia congenita
Malignant hyperthermia
Becker disease
Thomsen disease
1, 2 and 4 only
Sodium channel mutations cause paramyotonia congenita; calcium (RYR1-mediated) channel dysfunction is linked to malignant hyperthermia; and chloride channel (CLCN1) mutations cause Thomsen disease (myotonia congenita) — pairs 1, 2 and 4 are correct. Becker disease is a dystrophinopathy (muscular dystrophy) unrelated to the ryanodine receptor, making pair 3 incorrect.
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