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Question

Which of the following features are present in Locked-in syndrome?

1. Cerebral cortex is intact.

2. Bilateral motor tracts are damaged.

3. Some response to verbal stimuli may be present.

4. Limb movement occurs in response to noxious stimuli.

Select the correct answer using the code given below:

This question was previously asked in
UPSC CMS 2026 Surgery, Gynaecology & Obstetrics, and PSM Question Paper (02-Aug-2026)
The correct answer is

1, 2 and 3

Locked-in syndrome typically results from a ventral pontine lesion (often stroke) that damages bilateral corticospinal and corticobulbar tracts while sparing the cerebral cortex and ascending reticular activating system, so the patient is conscious and may respond to verbal stimuli via eye movements. Voluntary limb movement in response to noxious stimuli is absent due to quadriplegia, making statement 4 incorrect and 1, 2 and 3 the correct features.

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