The most common site for vulvar carcinoma is
labia majora
The correct answer is the labia majora. Vulvar carcinoma is 3–5% of female genital malignancies, occurs mostly in postmenopausal women, and is squamous cell carcinoma in about 90% of cases. The labia majora is the commonest site, accounting for roughly 50% of tumours. Two pathways exist: an HPV-16/18 related type in younger women from usual-type VIN, and an HPV-independent type in older women arising in lichen sclerosus. Spread is orderly to superficial inguinal, then deep inguinal (Cloquet’s node), then pelvic nodes, and nodal status is the strongest prognostic factor.
The labia minora is the second commonest site (15–20%), not the first. The clitoris is an uncommon primary site; its significance is that clitoral and anterior lesions may drain bilaterally, mandating bilateral groin dissection. The mons pubis is a rare primary site, usually involved only by contiguous extension of a large labial tumour.
Key point: Think of vulvar cancer as a postmenopausal woman with long-standing pruritus vulvae and an indurated ulcer on the labia majora; Stage IA (2 cm or less with 1 mm or less invasion) needs no groin node dissection.
Similar Questions
Point A in radiotherapy in carcinoma cervix marks the site for which of the following structures?
Which one of the following states the diagnostic criteria for postmolar gestational trophoblastic neoplasia?
Important Questions from Neoplasms in Genital Tract
- Which one of the following is a protective factor for endometrial hyperplasia?
- Tumor marker of epithelial ovarian carcinoma is:
- The most common site of cervical cancer is:
- Which of the following are the vaccines for prevention of cervical cancer?
1. Cervarix
2. Gardasil
3. T-dap
4. Influenza
Select the correct answer using the code given below: - Consider the following statements regarding Carcinoma Cervix:
1. Clinical staging is done
2. Treatment if provided in stage I leads to survival rate of 80–90%
3. Surgery is preferred in young women with stage III disease
4. HPV virus is considered to be the causative agent
Which of the statements given above are correct?
