A 50-year-old male working in a stone industry presents with breathlessness and cough. CT Chest shows calcified mediastinal lymph nodes and pulmonary nodules. He is diagnosed with silicosis. Which of the following statements are correct? 1. Silicosis typically involves lower lobes of the lung. 2. The patient is at a higher risk of developing pulmonary tuberculosis. 3. Pulmonary fibrosis after occupational exposure to silica is dose-dependent. Select the correct answer using the code given below:
2 and 3 only
Silicosis characteristically involves the upper lobes of the lung, not the lower lobes, making statement 1 incorrect. Silicosis is strongly associated with an increased risk of pulmonary tuberculosis (silicotuberculosis) due to impaired macrophage function (statement 2 correct), and the degree of pulmonary fibrosis correlates with cumulative silica dust exposure dose (statement 3 correct). Hence statements 2 and 3 only are correct.
Important Questions from Tuberculosis
Which of the following investigations may be used for the diagnosis of pulmonary tuberculosis?
1. Nucleic acid amplification
2. Culture in Middlebrook medium
3. Light emitting diode fluorescent microscopy with auramine staining
4. Peripheral blood smear
Select the correct answer using the code given below:
- Recommended first time drug for initial treatment of tuberculosis include all EXCEPT:
The most frequent adverse reaction of significance among people treated for drug-susceptible tuberculosis is:
All adult patients in whom anti-tubercular treatment is being started should undergo baseline assessment of:
- The extrapulmonary sites most commonly involved in tuberculosis are all EXCEPT:
