Question
The most frequent adverse reaction of significance among people treated for drug-susceptible tuberculosis is:
The correct answer is
Hepatitis
Tuberculosis Treatment Adverse Reactions Explained
Drug treatment regimens for tuberculosis (TB), particularly for drug-susceptible strains, can cause various side effects. Identifying the most frequent and clinically significant adverse reaction is key for patient management.
Identifying the Most Significant Adverse Reaction
Among the options provided, Hepatitis is recognized as the most frequent adverse reaction of significance in patients treated for drug-susceptible tuberculosis.
Reasoning for Significance
- Hepatotoxicity: Several first-line anti-TB drugs, including isoniazid, rifampicin, and pyrazinamide, carry a risk of causing liver damage (hepatitis).
- Clinical Impact: This reaction requires close monitoring of liver function tests. Significant hepatitis may necessitate dose adjustments, temporary cessation, or changes in the treatment regimen, potentially affecting treatment success.
- Frequency vs. Other Reactions: While other gastrointestinal or systemic side effects can occur, drug-induced hepatitis is often highlighted due to its potential severity and impact on treatment continuity.
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Important Questions from Tuberculosis
- For Acid Fast Bacilli (AFB) to be detected in sputum by the direct microscopy, the bacillary burden in sputum typically is:
A 65-year old man, on Warfarin treatment, is started on antitubercular treatment. The pharmacologic effect of Warfarin is likely to:
- The Gene X-pert test used for MTB detection has the additional advantage of detection of which of the following?
- Recommended first time drug for initial treatment of tuberculosis include all EXCEPT:
All adult patients in whom anti-tubercular treatment is being started should undergo baseline assessment of:
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