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Question

Which of the following membrane associated process involves the step of Clathrin coated vesicle formation during its mechanism ?

This question was previously asked in
MH SET 2024 Paper 2 Computer Science and Applications Question Paper (07-Apr-2024)
The correct answer is

Receptor mediated endocytosis

In receptor mediated endocytosis, ligands such as LDL or transferrin bind specific receptors that cluster in coated pits of the plasma membrane.

The cytosolic face of these pits is covered by a lattice of clathrin triskelions linked to the receptors through adaptor proteins (AP2); the pit invaginates and is pinched off by dynamin as a clathrin coated vesicle, which then sheds its coat and fuses with an early endosome.

Phagocytosis is an actin-driven engulfment of large particles by pseudopodia and does not depend on clathrin coats.

Amino acid uptake and calcium uptake occur through membrane transporters and channels (carriers, symporters, Ca2+ channels), which move solutes across the membrane without vesicle formation.

So clathrin coated vesicle formation is a step of receptor mediated endocytosis.

Hence, Receptor mediated endocytosis.

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