Which of the following is critical for differentiation of bipotential gonads towards ovarian pathway?
Wnt 4
The bipotential gonad of the early embryo can develop as either a testis or an ovary depending on which signalling pathway prevails in the somatic cells of the genital ridge.
Wnt4, together with Rspo1 and beta-catenin, drives the ovarian fate by promoting granulosa cell differentiation, supporting germ cell survival, and repressing the male programme.
SOX9 and FGF8 form the core feed-forward loop that specifies Sertoli cells and testis differentiation downstream of SRY, while BMP4 acts in mesoderm patterning and primordial germ cell induction rather than in ovary versus testis choice.
Hence, the correct choice is Wnt 4.
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