Rous sarcoma virus, which induces the formation of sarcomas in chickens. Which of the following is the product of oncogene V-src ?
Tyrosine Kinase
Rous sarcoma virus is a retrovirus that carries the oncogene v-src, the first oncogene discovered. Its cellular counterpart is the proto-oncogene c-src.
The v-src gene encodes pp60v-src, a non-receptor protein tyrosine kinase that phosphorylates target proteins on tyrosine residues. Unlike c-Src, it lacks the C-terminal regulatory tyrosine (Tyr527), so it is constitutively active and drives uncontrolled cell proliferation.
EGF is a growth factor (its receptor, not EGF itself, is related to the erb-B oncogene); tyrosinase is a melanin-synthesising enzyme; and serine/threonine kinases are products of oncogenes such as raf and mos, not src.
Hence, the answer is Tyrosine Kinase.
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