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Question

In the absence of oxygen, the metabolic fate of pyruvic acid will be :

This question was previously asked in
MH SET 2023 Paper 2 Computer Science and Applications Question Paper (26-Mar-2023)
The correct answer is

It will be utilized for reoxidation of NADH

Glycolysis reduces NAD+ to NADH at the glyceraldehyde-3-phosphate dehydrogenase step. Without oxygen the electron transport chain cannot reoxidise this NADH, so glycolysis would stop as soon as the NAD+ pool ran out.

In fermentation, pyruvate itself (lactate dehydrogenase in muscle and lactic bacteria) or its decarboxylation product acetaldehyde (alcohol dehydrogenase in yeast) acts as the electron acceptor, regenerating NAD+ so glycolysis can continue.

Complete oxidation of pyruvate to CO2 through the link reaction and the citric acid cycle requires oxygen as the final electron acceptor, so it cannot occur anaerobically. Pyruvate is reduced, not partially oxidised, in lactate fermentation, and its fate is set by oxygen supply rather than by energy need.

Hence, It will be utilized for reoxidation of NADH.

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