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Question

If a naive T cell recognizes an antigen-MHC complex on an appropriate antigen-presenting cell or target cell, it will be activated, initiating :

This question was previously asked in
MH SET 2020 Paper 2 Philosophy Question Paper (27-Dec-2020)
The correct answer is

a primary response

A naive T cell is a mature T cell that has left the thymus but has never met its specific antigen.

When its T-cell receptor recognizes the peptide–MHC complex on a suitable antigen-presenting cell (with co-stimulation), the naive cell is activated, proliferates (clonal expansion) and differentiates into effector and memory cells. This first exposure response is the primary immune response, which is slower and weaker.

A secondary response is produced by memory cells on a later exposure to the same antigen, so it cannot be started by a naive cell. Prophylactic response is not an immunological response category, and mast cell degranulation is triggered by allergen cross-linking of IgE bound to Fc receptors, not by T-cell recognition.

Hence, a primary response.

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