Consider the following statements with regard to point mutations: 1. If a purine is replaced by another purine, it is called 'transition'. 2. If a purine is replaced by a pyrimidine, it is called 'transversion'. 3. If a pyrimidine is replaced by another pyrimidine, it is called 'transversion'. Which of the statements given above are correct?
1 and 2 only
A transition is a substitution of a purine for a purine (A<->G) or a pyrimidine for a pyrimidine (C<->T). A transversion is a substitution of a purine for a pyrimidine or vice versa. Statement 3 is therefore incorrect since pyrimidine-to-pyrimidine substitution is a transition, not a transversion, making only statements 1 and 2 correct.
A 24 year old man presents with acute onset shortness of breath with precordial chest pain. ECG reveals ST elevation with upward concavity and PR segment depression in lead V2 to V6 and reciprocal changes in lead aVR. The most likely diagnosis is