Among following protein synthesis inhibitors which one causes misreading during translation ?
Streptomycin
Aminoglycosides bind the 30S ribosomal subunit; streptomycin is the classic example, binding 16S rRNA near the decoding A site and protein S12, which distorts codon–anticodon proofreading and causes misreading of mRNA.
Streptomycin-induced misreading (and phenotypic suppression) is the textbook demonstration of this effect, and streptomycin-resistant mutants map to the S12 gene (rpsL), linking misreading directly to this drug.
Hygromycin B acts mainly by blocking ribosomal translocation; kanamycin and neomycin are 2-deoxystreptamine aminoglycosides that also bind the decoding site, but they are best known as selectable resistance markers (nptII), while streptomycin is the prototype misreading agent.
So the inhibitor classically known to cause misreading is streptomycin.
Hence, Streptomycin.
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