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Question

A 70-year-old male, with a history of smoking presents with progressive dyspnea and dry cough. Examination reveals clubbing and fine basal crackles. Spirometry shows low forced vital capacity (FVC) and low diffusion capacity (DLCO). CT Chest shows extensive bilateral reticular shadows and subpleural honeycombing. What is the most likely diagnosis?

This question was previously asked in
UPSC CMS 2026 Surgery, Gynaecology & Obstetrics, and PSM Question Paper (02-Aug-2026)
The correct answer is

Idiopathic pulmonary fibrosis

Progressive dyspnea, dry cough, clubbing, fine bibasal crackles, a restrictive spirometry pattern (low FVC, low DLCO) and CT showing bilateral reticular shadows with subpleural honeycombing are the classic features of usual interstitial pneumonia pattern seen in Idiopathic Pulmonary Fibrosis. Sarcoidosis and COPD do not typically show honeycombing, and bronchiectasis shows a restrictive-obstructive picture with bronchial wall thickening rather than honeycombing.

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Important Questions from COPD

  1. The distance walked in 6 minutes is an indirect measure of which of the following variables of the 'BODE Index' which is used to assess the prognosis in chronic obstructive pulmonary disease?
  2. The most common cause of chronic type II respiratory failure is:
  3. Which of the following are categorised under obstructive lung disease ?
    1. Bronchial asthma
    2. Bronchiectasis
    3. Bronchiolitis
    4. Pulmonary sarcoidosis
    Select the correct answer using the code given below:
  4. Risk factors for development of COPD include which of the following ?
    1. Tobacco smoking
    2. Recurrent infection
    3. Coal dust exposure
    4. High socio-economic status
    Select the correct answer using the code given below:
  5. A 65-year-old male smoker has been diagnosed with Chronic Obstructive Pulmonary Disease (COPD). On pulmonary function testing, the $FEV_1/FVC < 0.7$ and $FEV_1 = 42\%$ of predicted. The severity of airflow obstruction in this patient as per GOLD criteria is :
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