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Question

A 6-year-old boy is brought with complaints of involuntary, non-rhythmic, jerky movements of upper limbs and snorting sounds, noticed for the past 12 months. His MRI brain and EEG are normal. The child was mocked at by classmates in school and he stopped attending classes for the past 6 months. His ASLO titres and serum ceruloplasmin are non-contributory. The ideal therapy would be a trial of:

This question was previously asked in
UPSC CMS 2026 Surgery, Gynaecology & Obstetrics, and PSM Question Paper (02-Aug-2026)
The correct answer is

Oral Clonidine

Chronic motor tics with a vocal component (snorting), normal MRI/EEG, and exclusion of Sydenham chorea (normal ASLO) and Wilson disease (normal ceruloplasmin) point to Tourette syndrome/chronic tic disorder. For mild-to-moderate tics, especially with psychosocial impact, alpha-2 agonists such as oral clonidine are first-line pharmacotherapy, reserving antipsychotics like olanzapine for severe, refractory tics.

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