The site of fatigue in neuromuscular junction is due to decreased release of ..............
Acetylcholine
At the neuromuscular junction, a nerve impulse causes the motor neuron terminal to release the neurotransmitter acetylcholine, which binds to receptors on the muscle fibre and triggers an action potential.
During prolonged or repeated stimulation, the store and rate of synthesis of acetylcholine fall, so less is released per impulse and transmission fails – this is neuromuscular (junctional) fatigue.
Ca++ and H+ accumulation and lactic acid are linked to fatigue inside the muscle fibre (excitation–contraction coupling and acidosis), not to reduced transmitter release at the junction.
Hence, fatigue at the neuromuscular junction is due to decreased release of Acetylcholine.
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