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Question

Resting membrane potential is :

This question was previously asked in
MH SET 2020 Paper 2 Philosophy Question Paper (27-Dec-2020)
The correct answer is

–70 mV

The resting membrane potential is the voltage difference across a neuron's membrane when it is not transmitting an impulse. Measured with a microelectrode, the inside of the neuron is about 70 millivolts more negative than the outside, i.e. about –70 mV.

This polarisation is maintained by the selective permeability of the membrane (more open to K+ than Na+), the sodium–potassium pump (3 Na+ out, 2 K+ in) and large negatively charged proteins trapped inside the cell. The value is negative because the potential is expressed as inside relative to outside, so +70 mV or +85 mV would describe the wrong polarity.

When depolarisation reaches threshold (about –55 mV) an action potential is triggered, after which the membrane repolarises and briefly hyperpolarises before returning to the resting value.

Hence, the answer is –70 mV.

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