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Question

Which among the following is the chief inhibiting neurotransmitter ?

This question was previously asked in
MH SET 2020 Paper 2 Philosophy Question Paper (27-Dec-2020)
The correct answer is

GABA

GABA (gamma-aminobutyric acid) is the chief inhibitory neurotransmitter of the central nervous system. Acting on GABAA receptors, it opens chloride channels, hyperpolarising the postsynaptic neuron and making it less likely to fire.

Anti-anxiety drugs such as benzodiazepines, as well as alcohol and barbiturates, enhance GABA activity, which explains their calming and sedative effects; low GABA activity is linked with anxiety and seizures.

Glutamate is the chief excitatory neurotransmitter; noradrenaline is involved in arousal and alertness; dopamine is involved in reward, movement and attention.

Hence, the answer is GABA.

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