Given below are two statements Statement I: Adenosine deaminase is crucial for the immune system to function. Statement II: Adenosine deaminase deficiency can be cured only by bone marrow transplantation. In the light of the above statements, choose the correct answer from the options given below.
Statement I is true, but Statement II is false
Adenosine deaminase (ADA) is an enzyme needed for the proper functioning of the immune system. A deletion of the ADA gene causes ADA deficiency, a severe immunodeficiency, and it was the first disease treated by gene therapy, in 1990, on a 4-year-old girl.
Statement I: ADA is crucial for the immune system to function — true; without it the lymphocytes fail and the child becomes immunodeficient.
Statement II: ADA deficiency can be cured only by bone marrow transplantation — false. Bone marrow transplantation is one treatment, enzyme replacement therapy (injecting functional ADA) is another, and gene therapy is a third. If the gene isolated from marrow cells producing ADA is introduced into cells at early embryonic stages, it could be a permanent cure. So the word "only" makes the statement wrong.
Since Statement I is true and Statement II is false, the choices calling both true, both false, or only Statement II true do not fit.
Statement I is true, but Statement II is false option is correct.
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b) Production of chain A and B separately.
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Statement II: E.coli having pBR322 with a desired DNA if inserted at BamHI site can grow in medium containing tetracycline.
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- Which of the following statements are not true regarding restriction endonucleases ?
A. They are called molecular scissors.
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D. They remove nucleotides only from the ends of DNA fragments.
E. They recognise specific palindromic base-pair sequences.
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A. The cutting of DNA is done by molecular scissors.
B. The DNA fragments separate according to their size in an agarose gel, upon electrophoresis.
C. The separated DNA fragments can be seen without staining when exposed to UV light.
D. The separated DNA fragments, when stained with ethidium bromide, can be seen in visible light.
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