A. Tetracycline inhibits protein synthesis through interference with the binding of aminoacyl-tRNA to 30S subunit of ribosome
B. Chloramphenicol inhibits protein synthesis by combining with the 50S subunit of ribosome
C. Erythromycin inhibits protein synthesis by binding on the 30S subunit of ribosome
D. Streptomycin inhibits protein synthesis by combining with 30S subunit of ribosome
Choose the correct answer from the options given below:
Antibiotic Mechanisms on Protein Synthesis
This question asks to identify the true statements regarding the mechanisms of action of specific antibiotics on bacterial protein synthesis.
Mechanism Analysis
Let's analyze each statement:
- Statement A (Tetracycline): Tetracyclines bind to the 30S ribosomal subunit and prevent the attachment of aminoacyl-tRNA to the mRNA-ribosome complex. This statement is True.
- Statement B (Chloramphenicol): Chloramphenicol binds to the 50S ribosomal subunit, inhibiting peptidyl transferase activity and blocking peptide bond formation. This statement is True.
- Statement C (Erythromycin): Erythromycin binds to the 50S ribosomal subunit and inhibits the translocation step of protein synthesis. The statement incorrectly claims it binds to the 30S subunit. This statement is False.
- Statement D (Streptomycin): Streptomycin, an aminoglycoside, binds to the 30S ribosomal subunit. It interferes with the initiation complex formation and causes misreading of the mRNA codons. This statement is True.
Conclusion
Based on the analysis, statements A, B, and D are true. Statement C is false.
Therefore, the correct combination is A, B and D Only.
This corresponds to Option 3.
Similar Questions
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A. Microprojectile
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D. Electroporation
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Repeated sequence TTAGGC in humans is present at :
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Important Questions from Mixed Topic (CUET PG)
- Kalpsutra, the illustrated canonical text is from:-
- The Harappan city almost exclusively devoted to craft production was-:
- Mohandas Karamchand Gandhi launched quit India movement after the failure of:-
- The "Objectives Resolution" was introduced in constituent assembly by:-
- Who among the following was not a member of the constituent assembly:-
