Question
Which of the following statements are True?
A. Tetracycline inhibits protein synthesis through interference with the binding of aminoacyl-tRNA to 30S subunit of ribosome
B. Chloramphenicol inhibits protein synthesis by combining with the 50S subunit of ribosome
C. Erythromycin inhibits protein synthesis by binding on the 30S subunit of ribosome
D. Streptomycin inhibits protein synthesis by combining with 30S subunit of ribosome
Choose the correct answer from the options given below:
This question was previously asked in
CUET PG 2026 Agri-Business Management Question Paper (25-Mar-2026) (Shift 2)
The correct answer is
A, B and D Only
Antibiotic Mechanisms on Protein Synthesis
This question asks to identify the true statements regarding the mechanisms of action of specific antibiotics on bacterial protein synthesis.
Mechanism Analysis
Let's analyze each statement:
- Statement A (Tetracycline): Tetracyclines bind to the 30S ribosomal subunit and prevent the attachment of aminoacyl-tRNA to the mRNA-ribosome complex. This statement is True.
- Statement B (Chloramphenicol): Chloramphenicol binds to the 50S ribosomal subunit, inhibiting peptidyl transferase activity and blocking peptide bond formation. This statement is True.
- Statement C (Erythromycin): Erythromycin binds to the 50S ribosomal subunit and inhibits the translocation step of protein synthesis. The statement incorrectly claims it binds to the 30S subunit. This statement is False.
- Statement D (Streptomycin): Streptomycin, an aminoglycoside, binds to the 30S ribosomal subunit. It interferes with the initiation complex formation and causes misreading of the mRNA codons. This statement is True.
Conclusion
Based on the analysis, statements A, B, and D are true. Statement C is false.
Therefore, the correct combination is A, B and D Only.
This corresponds to Option 3.
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