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Question

Select the correct sequence of steps involved in TCA cycle:

A. $\alpha$ Ketoglutarate
B. Succinyl CoA
C. Fumarate
D. Citrate
E. Oxaloacetate

Choose the correct answer from the options given below:

This question was previously asked in
CUET PG 2026 Agri-Business Management Question Paper (25-Mar-2026) (Shift 2)
The correct answer is
D, A, B, C, E

The question asks to identify the correct sequence of intermediates in the Tricarboxylic Acid (TCA) cycle.

TCA Cycle Intermediate Sequence

The key molecules mentioned are:

  • A. $\alpha$-Ketoglutarate
  • B. Succinyl CoA
  • C. Fumarate
  • D. Citrate
  • E. Oxaloacetate

Step-by-Step Pathway Analysis

Let's trace the sequence of these intermediates in the TCA cycle:

  1. The cycle begins with the formation of Citrate (D) from Acetyl-CoA and Oxaloacetate (E).
  2. Citrate (D) is subsequently converted through a series of reactions into $\alpha$-Ketoglutarate (A).
  3. $\alpha$-Ketoglutarate (A) is then converted into Succinyl CoA (B).
  4. Succinyl CoA (B) is further processed to yield Fumarate (C) (via Succinate).
  5. Finally, Fumarate (C) is converted back into Oxaloacetate (E) (via Malate), completing the cycle which then regenerates Citrate with Acetyl-CoA.

Based on this pathway, the correct sequence representing these specific intermediates is Citrate $\rightarrow$ $\alpha$-Ketoglutarate $\rightarrow$ Succinyl CoA $\rightarrow$ Fumarate $\rightarrow$ Oxaloacetate.

Identifying the Correct Option

Matching this sequence with the given labels:

  • D. Citrate
  • A. $\alpha$-Ketoglutarate
  • B. Succinyl CoA
  • C. Fumarate
  • E. Oxaloacetate

The sequence is D, A, B, C, E. This corresponds to option 2.

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