Assertion A: Bovine serum albumin (BSA) is not immunogenic when injected into cow but is strongly immunogenic when injected in rabbit.
Reason R: The greater the phylogenetic distance between two species, the less the structural disparity between them.
In the light of the above statements, choose the most appropriate answer from the options given below
Assertion A: BSA Immunogenicity Explained
Assertion A states that Bovine Serum Albumin (BSA) is not immunogenic when injected into cows but is strongly immunogenic when injected into rabbits.
This statement is correct. When a protein like BSA, originating from cows (bovine), is introduced into another cow, the cow's immune system recognizes it as a 'self' molecule. Therefore, it does not mount an immune response, and BSA is considered non-immunogenic in cows.
However, when BSA is injected into a different species, such as a rabbit, the rabbit's immune system identifies BSA as a foreign ('non-self') molecule. This triggers an immune response, leading to the production of antibodies against BSA, making it strongly immunogenic in rabbits.
Reason R: Phylogenetic Distance and Structural Disparity
Reason R claims that the greater the phylogenetic distance between two species, the less the structural disparity between them.
This statement is incorrect. Phylogenetic distance refers to the degree of evolutionary divergence between species. Species that are evolutionarily distant (i.e., share a distant common ancestor) generally have accumulated more genetic and structural differences over time. Conversely, species that are phylogenetically close (e.g., humans and chimpanzees) tend to have less structural disparity.
Therefore, a greater phylogenetic distance usually correlates with a greater structural disparity, not less.
Conclusion
Based on the analysis:
- Assertion A is correct because immune responses depend on recognizing foreign antigens.
- Reason R is incorrect because greater evolutionary distance typically leads to greater structural differences.
Thus, the correct option is that Assertion A is correct, but Reason R is not correct.
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