The following diagram represents energy states of different protein folding steps, which includes-
1. Folded
2. Transition
3. Molten globule
4. Unfolded
Find the correct match of folding steps (1 to 4) with the energy state (P to S) in the diagram.
To solve the question, we need to match the protein folding steps with the corresponding energy states in the provided diagram. The states are labeled as P, Q, R, and S along the energy profile.
- Folded State (1): This is the state where the protein is in its most stable and lowest energy form. In the diagram, this corresponds to point S at the end of the energy curve.
- Transition State (2): This is a high-energy state that occurs before reaching the stable folded state. It usually has an energy peak as seen in the diagram, which corresponds to point R.
- Molten Globule State (3): The molten globule is a partially folded state with lower energy than the unfolded state but higher than the folded state. It corresponds to the point Q in the diagram, which is lower than P but not as low as S.
- Unfolded State (4): This state is usually higher in energy than the folded state because it lacks the stability of a structured conformation. Point P represents the unfolded state, as it is at the highest point initially before energy starts decreasing.
Based on this analysis, the correct match of folding steps with the energy states is: 1-S, 2-R, 3-Q, 4-P.
Therefore, the correct answer is Option 1: 1-S, 2-R, 3-Q, 4-P.
Important Questions from Protein Structure Folding Alpha Helix
- A 25 amino acid $\alpha$-helical protein is spanning the thickness of a mammalian cell membrane. Using the average dimensional parameters of a typical $\alpha$-helix, the thickness of the membrane will be ________ $\text{\AA}$ (rounded off to one decimal place).
- In a $\alpha$-helix, the R-groups on the amino acid residues
- Which one of the following pairs of amino-acids in the protein has high propensity to take up the $\alpha$-helix conformation?
- Which one of the following closely defines 'Molten Globule' state of a protein?
In an individual, three distinct proteins bind oxygen depending on the location and development stage. While hemoglobin is the major oxygen binding protein in adults, myoglobin is present in skeletal muscles and fetal hemoglobin is present in fetal stage only. The following graph shows the oxygen binding capacity of these proteins. The A, B and C plots represent oxygen binding capacity of
