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Question

The correct sequence of transmission of pain/nociceptive stimulus from distal to proximal is :

A. Lateral spinothalamic tract

B. Transmission cells or T cells/Interneurons

C. Third order neuron

D. Dorsal root

E. Cerebral cortex

Choose the correct answer from the options given below :

This question was previously asked in
CUET PG 2026 Agri-Business Management Question Paper (25-Mar-2026) (Shift 2)
The correct answer is
D, B, A, C, E

Understanding Pain Stimulus Transmission

The question asks to identify the correct sequence for the transmission of a pain or nociceptive stimulus, moving from the periphery (distal) towards the central nervous system and brain (proximal).

Tracing the Nociceptive Pathway

The pathway involves several key structures and neuronal components:

  • Dorsal root (D): This is where sensory nerve fibers, carrying the initial stimulus from the periphery, enter the spinal cord.
  • Transmission cells or T cells/Interneurons (B): Within the dorsal horn of the spinal cord, the primary sensory neuron synapses with secondary neurons. These are often transmission cells or interneurons that process and relay the signal.
  • Lateral spinothalamic tract (A): The secondary neurons typically cross to the opposite side of the spinal cord and ascend towards the brain via the lateral spinothalamic tract, a major pathway for pain and temperature.
  • Third order neuron (C): Neurons originating in the thalamus (a relay station in the brain) form the third-order neurons. These project from the thalamus to the cerebral cortex.
  • Cerebral cortex (E): This is the final destination where the pain stimulus is consciously perceived and interpreted.

Sequencing the Neural Transmission

Following the path from distal to proximal:

  1. The stimulus enters the spinal cord via the Dorsal root (D).
  2. It synapses with Transmission cells/Interneurons (B) in the spinal cord.
  3. The signal ascends via the Lateral spinothalamic tract (A).
  4. From the thalamus, the Third order neuron (C) carries the signal further.
  5. The signal reaches the Cerebral cortex (E) for perception.

Therefore, the correct sequence is D, B, A, C, E.

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