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Some of the routes of administration of drug are oral, close Intra-arterial injection, Intramuscular, rectal and transdermal therapeutic systems. Out of the above which one is considered as a local route of drug administration ?

This question was previously asked in
CUET PG 2026 Agri-Business Management Question Paper (25-Mar-2026) (Shift 2)
The correct answer is
Close intra-arterial injections

Analyzing Routes of Drug Administration

The question asks to identify the route of drug administration considered 'local' from the given options. A local route targets a specific area of the body, while a systemic route distributes the drug throughout the body.

Understanding Local vs. Systemic Routes

  • Local Administration: The drug acts directly at the site of application or is targeted to a specific nearby tissue.
  • Systemic Administration: The drug enters the bloodstream and circulates throughout the body, affecting multiple organs.

Evaluating Administration Routes

  • Oral: Primarily a systemic route; drugs are absorbed through the digestive tract into the bloodstream.
  • Intramuscular: Can be local (e.g., vaccines) or systemic depending on the drug and absorption rate. It's regional initially.
  • Rectal: Can be both; some drugs act locally in the rectum, while others are absorbed systemically.
  • Transdermal therapeutic systems: Designed for systemic absorption through the skin over time.
  • Close intra-arterial injections: This involves injecting the drug directly into an artery supplying a specific organ or tissue (e.g., chemotherapy for a tumor). The drug's action is highly localized to the area perfused by that artery.

Conclusion on Local Route

Among the options provided, Close intra-arterial injections are specifically designed to deliver the drug to a localized area, making it the most appropriate answer for a local route of administration. The intent is to achieve a high concentration of the drug in the target tissue while minimizing systemic exposure.

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