Question
The correct order of events of Cori cycle after muscular activity is : A. Conversion of glycogen to glucose in muscle B. Reoxidation of lactate to pyruvate in liver C. Gluconeogenesis of pyruvate in liver D. Production of pyruvate in muscle E. Reduction of pyruvate to lactate in muscle which goes to liver Choose the correct answer from the options given below :
This question was previously asked in
CUET PG 2026 Agri-Business Management Question Paper (25-Mar-2026) (Shift 2)
The correct answer is
A, D, E, B, C
Cori Cycle Events Order
The Cori cycle describes the metabolic pathway connecting anaerobic glycolysis in muscles with gluconeogenesis in the liver.
Muscular Activity and Lactate Processing
- Glycogen Breakdown & Glycolysis: In muscles, stored glycogen is converted to glucose (A). Glucose then undergoes glycolysis, producing pyruvate ($C_3H_4O_3$) (D).
- Lactate Formation: During strenuous activity, when oxygen supply is limited, muscle pyruvate ($C_3H_4O_3$) is reduced to lactate ($C_3H_5O_3$) (E) to regenerate $NAD^+$.
- Lactate Transport: Lactate ($C_3H_5O_3$) produced in the muscles is released into the bloodstream and transported to the liver.
- Liver Processing: In the liver, lactate ($C_3H_5O_3$) is reoxidized back to pyruvate ($C_3H_4O_3$) (B).
- Gluconeogenesis: The liver pyruvate ($C_3H_4O_3$) then serves as a substrate for gluconeogenesis, synthesizing new glucose molecules (C).
- Glucose Returns: This newly synthesized glucose is released into circulation and returns to the muscles, ready for reuse.
Determining the Correct Sequence
The correct chronological order of events is:
A (Glycogen to glucose in muscle) → D (Pyruvate production in muscle) → E (Pyruvate reduction to lactate in muscle) → B (Lactate reoxidation to pyruvate in liver) → C (Gluconeogenesis of pyruvate in liver).
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