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Question

SAM is required for ........ reaction.

This question was previously asked in
MH SET 2024 Paper 2 Computer Science and Applications Question Paper (07-Apr-2024)
The correct answer is

Methylation

SAM is S-adenosylmethionine, formed in the body from the amino acid methionine and ATP by the enzyme methionine adenosyltransferase.

Its sulphonium ion carries an activated methyl group, making it the universal methyl donor for transmethylation reactions such as the synthesis of creatine, epinephrine, phosphatidylcholine and the methylation of DNA.

After donating the methyl group it becomes S-adenosylhomocysteine and then homocysteine, which is remethylated using folate and vitamin B12.

Removal of amino groups, removal of carboxyl groups and oxidation reactions use other cofactors such as pyridoxal phosphate, NAD and FAD rather than this methyl donor.

Hence, Methylation.

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