Column I Column II P. Veratrum alkaloids (i) Obesity Q. Thalidomide (ii) Minamata syndrome R. Methylmercury (iii) Cyclopia S. Diethylstilbesterol (iv) Phocomelia
Exam Solution: Matching Developmental Defects and Chemical Agents
This solution details the correct pairings between specific drugs/chemicals listed in Column I and the developmental or physiological defects mentioned in Column II.
Correct Matches Explained
The question requires matching teratogenic agents or chemicals with their known associated defects.
| Column I: Drug/Chemical | Column II: Defect | Association |
| P. Veratrum alkaloids | (iii) Cyclopia | Veratrum alkaloids are known teratogens that can cause cyclopia, a severe congenital disorder characterized by a single eye socket. |
| Q. Thalidomide | (iv) Phocomelia | Thalidomide, famously used in the mid-20th century, is strongly linked to phocomelia, a condition where limbs are abnormally short or absent. |
| R. Methylmercury | (ii) Minamata syndrome | Methylmercury poisoning, especially from contaminated fish, leads to severe neurological damage, classically known as Minamata syndrome. |
| S. Diethylstilbesterol | (i) Obesity | In utero exposure to Diethylstilbesterol (DES) has been associated with various endocrine and reproductive abnormalities, with potential links to metabolic dysregulation including obesity. |
Based on these established associations, the correct matching is P-(iii); Q-(iv); R-(ii); S-(i).
Important Questions from Numerical Relations
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