Question
Match List I with List IIList I List II A. Receptor Tyrosine Kinase I. $Ca^{2+}$ and diacylglycerol B. Protein Kinase A II. cAMP C. Protein Kinase C III. Phosphatidylinositol 3,4,5-trisphosphate (PIP3) D. PI3K IV. Ras
Choose the correct answer from the options given below:
This question was previously asked in
CUET PG 2026 Agri-Business Management Question Paper (25-Mar-2026) (Shift 2)
The correct answer is
A-IV, B-II, C-I, D-III
Solution Breakdown
This question requires matching components from List I with their corresponding signaling molecules or downstream effectors from List II in cell signaling pathways.
- A. Receptor Tyrosine Kinase (RTK): Upon activation, RTKs initiate signaling cascades. A key downstream event involves the activation of the small GTPase Ras (IV), which acts as an important signal transducer.
- B. Protein Kinase A (PKA): PKA is a serine/threonine kinase that is regulated by the second messenger cyclic AMP (cAMP) (II). Increased cAMP levels activate PKA.
- C. Protein Kinase C (PKC): Conventional isoforms of Protein Kinase C are activated by second messengers produced during signal transduction, specifically diacylglycerol (DAG) and increased intracellular calcium ions ($Ca^{2+}$) (I).
- D. PI3K (Phosphoinositide 3-kinase): PI3K enzymes are lipid kinases that phosphorylate the 3'-hydroxyl group of phosphoinositides. Their product, phosphatidylinositol (3,4,5)-trisphosphate (PIP3) (III), is a crucial second messenger that recruits downstream signaling proteins.
Correct Matching
The established biological pairings are:
- Receptor Tyrosine Kinase (RTK) activates Ras (A-IV).
- Protein Kinase A (PKA) is activated by cAMP (B-II).
- Protein Kinase C (PKC) is activated by $Ca^{2+}$ and diacylglycerol (C-I).
- PI3K generates PIP3 (D-III).
Therefore, the correct match is A-IV, B-II, C-I, D-III.
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