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Question

Given below are two statements: one is labelled as Assertion A and the other is labelled as Reason R

Assertion A: Cardiac excitation normally begins in the sinoatrial (SA) node.

Reason R: SA node cells do not have a stable resting potential. They depolarize to threshold spontaneously.

In the light of the above statements, choose the most appropriate answer from the options given below

This question was previously asked in
CUET PG 2026 Agri-Business Management Question Paper (25-Mar-2026) (Shift 2)
The correct answer is
Both A and R are correct and R is the correct explanation of A

Cardiac Excitation Analysis: SA Node Function

This question asks us to evaluate two statements regarding the origin of cardiac excitation and the properties of the SA node.

Assertion A Analysis

Assertion A states that cardiac excitation normally begins in the sinoatrial (SA) node. This is a fundamental concept in cardiovascular physiology. The SA node, located in the upper wall of the right atrium, acts as the heart's natural pacemaker. It initiates the electrical impulse that triggers atrial contraction and subsequently leads to ventricular contraction, thus controlling the heart rate.

  • Assertion A is correct.

Reason R Analysis

Reason R states that SA node cells do not have a stable resting potential and depolarize to threshold spontaneously. This property is known as automaticity. Unlike typical cardiac muscle cells or neurons that maintain a stable negative resting membrane potential, SA node cells exhibit a "pacemaker potential." Their membrane potential gradually drifts towards the threshold potential without external stimulation, causing them to fire action potentials rhythmically.

  • Reason R is correct.

Relationship Between Assertion A and Reason R

The spontaneous depolarization (automaticity) described in Reason R is precisely the mechanism that allows the SA node to act as the primary pacemaker and initiate cardiac excitation, as stated in Assertion A. Because the SA node cells can generate impulses spontaneously and rhythmically, they set the pace for the entire heart.

  • Therefore, Reason R provides the correct physiological explanation for why Assertion A is true.

Conclusion

Both statements are factually correct, and Reason R accurately explains Assertion A.

The most appropriate answer is: Both A and R are correct and R is the correct explanation of A.

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