Question
Approaches to drug discovery and clinical trial of a compound : A. Therapeutic confirmation/comparison B. Micro dosing study C. Human pharmacology and safety D. Therapeutic exploration and dose ranging E. Post marketing surveillance/data gathering Choose the correct answer from the options given below :
This question was previously asked in
CUET PG 2026 Agri-Business Management Question Paper (25-Mar-2026) (Shift 2)
The correct answer is
B, C, D, A, E
Drug Discovery and Clinical Trial Sequence Explained
The process of developing a new drug involves several sequential stages, starting from early safety assessments in humans to post-approval monitoring. Understanding this order is crucial for drug development.
Correct Clinical Trial Phase Sequence
The correct sequence of the provided approaches in drug discovery and clinical trials is:
- B. Micro dosing study: This early phase (sometimes called Phase 0) uses very small, sub-therapeutic doses to gather preliminary data on how the drug is processed by the body (pharmacokinetics) and its potential effects, minimizing risk.
- C. Human pharmacology and safety: This corresponds to Phase I trials. It involves the first administration of the drug to a small group of healthy volunteers to assess safety, determine a safe dosage range, and understand pharmacokinetics and pharmacodynamics.
- D. Therapeutic exploration and dose ranging: This aligns with Phase II trials. The drug is given to a limited number of patients with the target condition to evaluate its effectiveness (efficacy) and further refine the dosage.
- A. Therapeutic confirmation/comparison: This represents Phase III trials. The drug is tested on a large, diverse group of patients to confirm its effectiveness, monitor side effects, compare it to standard treatments, and collect information for safe use.
- E. Post marketing surveillance/data gathering: This is Phase IV, occurring after the drug is approved and available to the public. It involves ongoing monitoring of the drug's safety and effectiveness in the real world.
Therefore, the correct order is B, C, D, A, E.
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