Lip Squamous Cell Carcinoma: Understanding Correct Statements
To identify the correct statement regarding squamous cell carcinoma (SCC) of the lip, let's analyze each option:
- Option 1: Lymph node metastases occur early
While lymph node metastasis can occur, it is generally considered less frequent and often occurs later in the course of lip SCC compared to some other head and neck cancers. This statement is not consistently correct. - Option 2: More than 90 per cent of cases occur on the upper lip
This is incorrect. Squamous cell carcinoma of the lip predominantly affects the lower lip, accounting for the vast majority of cases (typically 80-90%). - Option 3: Lesion often arises in the areas of persistent hyperkeratosis
This statement is correct. Lip SCC frequently develops from pre-existing chronic lip changes, such as actinic cheilitis, which is characterized by dryness, scaling, and persistent hyperkeratosis due to chronic sun exposure. Leukoplakia can also be a precursor. - Option 4: Radiotherapy is considered inappropriate treatment for these lesions
This is incorrect. Radiotherapy is a recognized and often effective treatment modality for lip SCC, especially for more advanced or larger lesions, or when surgical excision poses significant functional or cosmetic challenges.
Conclusion on Lip SCC Characteristics
Based on the analysis, the most accurate statement describing squamous cell carcinoma of the lip is that the lesion often develops in areas exhibiting persistent hyperkeratosis, indicative of pre-cancerous changes like actinic cheilitis.
Important Questions from Tumours
Which types of cancer are associated with exposure to ionizing radiation?
1. Leukaemia
2. Lung cancer
3. Breast cancer
4. Lymphoma
Select the correct answer using the code given below.
Which of the following are correct regarding Li-Fraumeni syndrome?
1. It has autosomal dominant inheritance and is associated with P53 gene.
2. It has autosomal recessive inheritance and is associated with P53 gene.
3. It is associated with an increased risk of sarcomas and leukaemia.
4. It is associated with an increased risk of brain tumours and osteo- sarcomas.
Select the answer using the code given below.
- A 25 year old female patient with previous history of neck irradiation presents with thyroid swelling for last 6 months. The patient is clinically euthyroid. On examination, the right lobe of thyroid gland is enlarged with presence of ipsilateral cervical lymphadenopathy. The most probable clinical diagnosis in this patient is
Which of the following statements regarding Carcinoid tumour are correct?
1. Terminal ileum is the most common site for these tumours in the gastrointestinal tract
2. These tumors arise from Kulchitsky cells situated at the base of intestinal crypts
3. 5-Hydroxytryptamine is the most common vasoactive peptide produced by these tumors
4. Serum chromogranin A is a useful marker for disease recurrence
Select the correct answer using the code given below :
- Which one of the following is correct regarding Gastrointestinal Stromal Tumour (GIST)?
