BRCA1/BRCA2 Gene Association with Cancers
BRCA1 and BRCA2 are genes crucial for DNA repair. Mutations in these genes significantly increase the risk of developing certain types of cancer.
Known Associated Cancers
Mutations in BRCA1/BRCA2 significantly elevate the risk for:
- Breast cancer
- Ovarian cancer
- Prostate cancer
- Pancreatic cancer
Cancer NOT Associated with BRCA1/BRCA2
Among the options provided, Liver cancer is not typically associated with inherited mutations in the BRCA1 or BRCA2 genes. While BRCA mutations predispose individuals to specific hereditary cancer syndromes, liver cancer is not a primary feature of these syndromes.
Therefore, liver cancer is the correct answer as it is NOT associated with BRCA1/BRCA2 genes.
Important Questions from Tumours
Which types of cancer are associated with exposure to ionizing radiation?
1. Leukaemia
2. Lung cancer
3. Breast cancer
4. Lymphoma
Select the correct answer using the code given below.
Which of the following are correct regarding Li-Fraumeni syndrome?
1. It has autosomal dominant inheritance and is associated with P53 gene.
2. It has autosomal recessive inheritance and is associated with P53 gene.
3. It is associated with an increased risk of sarcomas and leukaemia.
4. It is associated with an increased risk of brain tumours and osteo- sarcomas.
Select the answer using the code given below.
- A 25 year old female patient with previous history of neck irradiation presents with thyroid swelling for last 6 months. The patient is clinically euthyroid. On examination, the right lobe of thyroid gland is enlarged with presence of ipsilateral cervical lymphadenopathy. The most probable clinical diagnosis in this patient is
Which of the following statements regarding Carcinoid tumour are correct?
1. Terminal ileum is the most common site for these tumours in the gastrointestinal tract
2. These tumors arise from Kulchitsky cells situated at the base of intestinal crypts
3. 5-Hydroxytryptamine is the most common vasoactive peptide produced by these tumors
4. Serum chromogranin A is a useful marker for disease recurrence
Select the correct answer using the code given below :
- Which one of the following is correct regarding Gastrointestinal Stromal Tumour (GIST)?
