GIST Facts Explained
Correct GIST Characteristics
Gastrointestinal Stromal Tumours (GIST) are a distinct class of mesenchymal neoplasms. Understanding their key features is crucial.
Stomach Location: The stomach is the most common site for GIST, accounting for approximately 50% of all occurrences.
- Demographics: The ratio of males to females affected by GIST is roughly equal, typically ranging from 1:1 to 1.5:1.
- Metastasis Pattern: Lymphatic spread is uncommon in GIST. Hematogenous (bloodborne) spread is the more prevalent pattern for distant metastasis.
Incorrect GIST Assertions
- Option 1 is incorrect because GIST arises from mesenchymal cells (like interstitial cells of Cajal precursors), not the epithelial layer.
- Option 2 is incorrect as the male to female ratio is not 9:1.
- Option 4 is incorrect because lymphatic spread is rare in GIST.
Important Questions from Tumours
Which types of cancer are associated with exposure to ionizing radiation?
1. Leukaemia
2. Lung cancer
3. Breast cancer
4. Lymphoma
Select the correct answer using the code given below.
Which of the following are correct regarding Li-Fraumeni syndrome?
1. It has autosomal dominant inheritance and is associated with P53 gene.
2. It has autosomal recessive inheritance and is associated with P53 gene.
3. It is associated with an increased risk of sarcomas and leukaemia.
4. It is associated with an increased risk of brain tumours and osteo- sarcomas.
Select the answer using the code given below.
- A 25 year old female patient with previous history of neck irradiation presents with thyroid swelling for last 6 months. The patient is clinically euthyroid. On examination, the right lobe of thyroid gland is enlarged with presence of ipsilateral cervical lymphadenopathy. The most probable clinical diagnosis in this patient is
Which of the following statements regarding Carcinoid tumour are correct?
1. Terminal ileum is the most common site for these tumours in the gastrointestinal tract
2. These tumors arise from Kulchitsky cells situated at the base of intestinal crypts
3. 5-Hydroxytryptamine is the most common vasoactive peptide produced by these tumors
4. Serum chromogranin A is a useful marker for disease recurrence
Select the correct answer using the code given below :
- Which one of the following is NOT associated with BRCA1/BRCA2 genes ?
