Question
Which one of the following is correct regarding Gastrointestinal Stromal Tumour (GIST)?
The correct answer is
50% arise from stomach.
GIST Facts Explained
Correct GIST Characteristics
Gastrointestinal Stromal Tumours (GIST) are a distinct class of mesenchymal neoplasms. Understanding their key features is crucial.
Stomach Location: The stomach is the most common site for GIST, accounting for approximately 50% of all occurrences.
- Demographics: The ratio of males to females affected by GIST is roughly equal, typically ranging from 1:1 to 1.5:1.
- Metastasis Pattern: Lymphatic spread is uncommon in GIST. Hematogenous (bloodborne) spread is the more prevalent pattern for distant metastasis.
Incorrect GIST Assertions
- Option 1 is incorrect because GIST arises from mesenchymal cells (like interstitial cells of Cajal precursors), not the epithelial layer.
- Option 2 is incorrect as the male to female ratio is not 9:1.
- Option 4 is incorrect because lymphatic spread is rare in GIST.
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Important Questions from Tumours
- Which one of the following is NOT correct regarding MEN-1 syndrome?
- All of the following are hormonal agents used in treatment of cancer EXCEPT:
- Which one of the following is NOT associated with BRCA1/BRCA2 genes ?
Which of the following are correct regarding Li-Fraumeni syndrome?
1. It has autosomal dominant inheritance and is associated with P53 gene.
2. It has autosomal recessive inheritance and is associated with P53 gene.
3. It is associated with an increased risk of sarcomas and leukaemia.
4. It is associated with an increased risk of brain tumours and osteo- sarcomas.
Select the answer using the code given below.
- Which of the following are correct about glomus tumour?
1. It arises from Sucquet-Hoyer canals.
2. Its usual site is nail bed.
3. It is usually a small purple nodule.
4. It is painless.
Select the correct answer using the code given below.
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