MEN-1 Syndrome: Pineal Gland Involvement Analysis
The question asks to identify the organ NOT typically associated with MEN-1 syndrome among the given options. MEN-1, also known as Wermer's syndrome, is a genetic disorder affecting multiple endocrine glands.
Understanding MEN-1 Syndrome
MEN-1 syndrome is characterized by the development of tumors in several endocrine glands. The classic triad involves:
- Parathyroid glands: Overactivity leading to primary hyperparathyroidism is the most common feature.
- Pituitary gland: Tumors like adenomas can occur, often affecting prolactin or growth hormone levels.
- Pancreatic islet cells: Tumors such as gastrinomas (causing Zollinger-Ellison syndrome) or insulinomas are common.
Evaluating the Options
Based on the known features of MEN-1:
- Option 1: Parathyroid glands - Correctly involved in MEN-1.
- Option 2: Pancreas - Correctly involved in MEN-1.
- Option 3: Pituitary gland - Correctly involved in MEN-1.
- Option 4: Pineal gland - This gland is NOT part of the classic MEN-1 triad. While non-endocrine tumors can occur in MEN-1 patients, pineal tumors are not a characteristic feature.
Therefore, the statement that the pineal gland involves MEN-1 is incorrect.
Important Questions from Tumours
- All of the following are hormonal agents used in treatment of cancer EXCEPT:
- Which one of the following is NOT associated with BRCA1/BRCA2 genes ?
Which of the following are correct regarding Li-Fraumeni syndrome?
1. It has autosomal dominant inheritance and is associated with P53 gene.
2. It has autosomal recessive inheritance and is associated with P53 gene.
3. It is associated with an increased risk of sarcomas and leukaemia.
4. It is associated with an increased risk of brain tumours and osteo- sarcomas.
Select the answer using the code given below.
- Which one of the following is correct regarding Gastrointestinal Stromal Tumour (GIST)?
- Which of the following are correct about glomus tumour?
1. It arises from Sucquet-Hoyer canals.
2. Its usual site is nail bed.
3. It is usually a small purple nodule.
4. It is painless.
Select the correct answer using the code given below.
