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Question

Which one of the following DNA sequences carries an invert repeat?

The correct answer is
ATGAGCCGGCTCTA TACTCGGCCGAGAT

DNA Invert Repeat Definition

An inverted repeat (IR) is a sequence of DNA that reads the same forwards on one strand as it does backwards on the complementary strand. This means the sequence is identical to its reverse complement. A common form is $S...RC(S)$, where $RC(S)$ is the reverse complement of $S$. A sequence that is its own reverse complement is called a palindrome.

Sequence Analysis for Invert Repeats

We examine the given DNA sequences to identify which one contains an inverted repeat.

Option B: Identifying the Invert Repeat

Let's analyze Option B: $ATGAGCCGGCTCTA TACTCGGCCGAGAT$.

The complete sequence is:

$ATGAGCCGGCTCTATACTCGGCCGAGAT$

This sequence contains the subsequence $CCGG$ appearing twice:

  • The first instance of $CCGG$ starts at position 7.
  • The second instance of $CCGG$ starts at position 20 (using 1-based indexing).

The subsequence $CCGG$ is a palindrome, meaning it is its own reverse complement ($RC(CCGG) = CCGG$). The presence of this palindromic sequence repeated within the larger DNA strand constitutes an inverted repeat structure ($CCGG...CCGG$).

Therefore, Option B carries an inverted repeat.

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Important Questions from Molecular Structure of Genes and Chromosomes

  1. All pseudogenes DO NOT code for a __________.
  2. C-value paradox refers to
  3. DNA sample collected from an unidentified bacterial species (Y) contains 13% of adenine. The G+C content (in percentage) of Y is ________
  4. The contour length of a B-DNA molecule that encodes a bacterial protein of 33 kDa is _________ nm. 

    Consider the average molecular weight of an amino acid as 110 Da and helix rise per base pair for B-DNA as 0.34 nm. 

    (Round off to the nearest integer)

  5. Which of the following methods is/are used for identifying histone modifications?
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